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Questions

Question 1

What is one of the principal effects of cortisol on the protein stores in essentially all body cells, with the exception of the liver?

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Question 2

While cortisol reduces proteins elsewhere in the body, what is its effect on liver and plasma proteins?

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Question 3

According to the text, the reduction of cellular protein caused by cortisol results from which two mechanisms?

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Question 4

What is a potential consequence of excessive cortisol levels on muscle function?

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Question 5

How does cortisol specifically affect the transport of amino acids into muscle cells versus hepatic cells?

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Question 6

How does insulin promote protein synthesis and storage with respect to amino acids?

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Question 7

Which of the following groups of amino acids is identified as being most strongly transported into cells by insulin?

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Question 8

What is the described effect of insulin on the ribosomal machinery related to protein synthesis?

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Question 9

How does insulin's action in the liver contribute to the conservation of amino acids in the body's protein stores?

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Question 10

In a state of insulin deficiency, such as in severe diabetes mellitus, what happens to protein metabolism?

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Question 11

What is the overall effect of thyroid hormones on protein metabolism?

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Question 12

What is the consequence of long-term, markedly increased levels of thyroid hormone on heart muscle strength?

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Question 13

What is the primary effect of testosterone on protein deposition and muscle development?

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Question 14

By approximately what percentage is the muscle mass of a post-pubertal male greater than that of a female, on average, due to testosterone's effects?

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Question 15

What is the primary effect of estrogens on total body protein?

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Question 16

The anabolic protein effect of testosterone leads to an increase in which component of bone?

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Question 17

What is the consequence of estrogen deficiency after menopause on the bones?

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Question 18

What is the primary mechanism by which insulin inhibits protein catabolism, especially in muscle cells?

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Question 19

What is the effect of an adrenocortical tumor that secretes excessive quantities of androgens in a female?

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Question 20

The synergistic action of insulin and growth hormone is necessary for significant growth because each hormone promotes the cellular uptake of what?

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Question 21

In the presence of excess cortisol, the immunity functions of which tissue type can be decreased to a small fraction of normal?

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Question 22

What is the believed reason for cortisol's differential effect of increasing liver proteins while reducing them in other tissues?

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Question 23

An adult male who is nonathletic but has normal testosterone levels will have muscles that are approximately how much larger than a comparable female without testosterone?

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Question 24

In a state of insulin deficiency, the degradation of amino acids leads to an enhanced excretion of what substance in the urine?

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Question 25

Besides its effect on muscles, where else does testosterone cause significant deposition of proteins?

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Question 26

What is the primary cause of muscle weakness in a person with hyperthyroidism?

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Question 27

Which of the following hormones has its protein anabolic function specifically cited as the reason for an increase in bone matrix?

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Question 28

What is the effect of administering only insulin or only growth hormone to a rat that is both depancreatized and hypophysectomized?

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Question 29

What effect does cortisol have on the formation of RNA in many extrahepatic tissues like muscle and lymphoid tissue?

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Question 30

In a state of severe diabetes mellitus, protein wasting is considered one of the most serious effects and can lead to what?

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Question 31

The protein anabolic effect of estrogen is much less powerful than that of testosterone and is most evident by a slight positive balance of what element?

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Question 32

What is the effect of a slight excess versus a markedly increased level of thyroid hormone on heart strength?

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Question 33

When does cortisol typically mobilize the basic functional proteins of cells, such as muscle contractile proteins?

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Question 34

A longer-term effect of insulin is to increase the rate of transcription of selected DNA genetic sequences, leading to the formation of what?

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Question 35

What is the effect of estrogen deficiency in old age on bone?

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Question 36

In severe hyperthyroidism, some severely thyrotoxic patients may die of cardiac decompensation. This is secondary to myocardial failure and what other factor related to protein metabolism?

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Question 37

What is the primary role of the increased plasma amino acid concentration caused by cortisol?

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Question 38

A male without functional testes does not develop male pattern baldness, even with a genetic predisposition. This indicates that baldness is dependent on the genetic background and what other factor?

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Question 39

How does the effect of estrogens on protein deposition compare to that of testosterone?

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Question 40

In a person with Cushing syndrome, what is the effect on tissue proteins almost everywhere in the body, with the exception of the liver?

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Question 41

What is the primary reason that a slight excess of thyroid hormone can increase heart strength?

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Question 42

What is the effect of insulin deficiency on plasma amino acid concentration?

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Question 43

Loss of protein from which specific tissue in Cushing's syndrome leads to severe weakness?

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Question 44

What is the impact of Cushing syndrome on the protein collagen fibers in subcutaneous tissue?

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Question 45

What is the effect of thyroid hormones on the rate of protein synthesis?

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Question 46

How does insulin deficiency lead to increased plasma amino acids?

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Question 47

Massive quantities of glucocorticoids, as seen in Cushing syndrome, have what specific effect on osteoblastic activity?

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Question 48

Besides the general protein anabolic function, what other factor contributes to the increase in bone matrix caused by testosterone?

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Question 49

In the context of hyperthyroidism, excessive skeletal growth can occur in children, but what is the ultimate effect on their adult height?

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Question 50

What is the primary function of the protein 'calbindin' in relation to vitamin D's effect on calcium absorption?

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Other chapters

Functional Organization of the Human Body and Control of the “Internal Environment”The Cell and Its FunctionsGenetic Control of Protein Synthesis, Cell Function, and Cell ReproductionTransport of Substances Through Cell MembranesMembrane Potentials and Action PotentialsContraction of Skeletal MuscleExcitation of Skeletal Muscle: Neuromuscular Transmission and Excitation-Contraction CouplingExcitation and Contraction of Smooth MuscleCardiac Muscle; The Heart as a Pump and Function of the Heart ValvesRhythmical Excitation of the HeartThe Normal ElectrocardiogramCardiac Arrhythmias and Their Electrocardiographic InterpretationThe Circulation: Overview of the Circulation; Medical Physics of Pressure, Flow, and ResistanceVascular Distensibility and Functions of the Arterial and Venous SystemsThe Microcirculation and the Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph FlowLocal and Humoral Control of Tissue Blood FlowNervous Regulation of the Circulation and Rapid Control of Arterial PressureCardiac Output, Venous Return, and Their RegulationMuscle Blood Flow and Cardiac Output During Exercise; the Coronary Circulation and Ischemic Heart DiseaseCardiac FailureCirculatory Shock and Its TreatmentThe Body Fluid Compartments: Extracellular and Intracellular Fluids; Interstitial Fluid and EdemaUrine Formation by the Kidneys: I. Glomerular Filtration, Renal Blood Flow, and Their ControlUrine Formation by the Kidneys: II. Tubular Reabsorption and SecretionRenal Regulation of Potassium, Calcium, Phosphate, and Magnesium; Integration of Renal Mechanisms for Control of Blood Volume and Extracellular Fluid VolumeRegulation of Acid-Base BalanceKidney Diseases and DiureticsRed Blood Cells, Anemia, and PolycythemiaResistance of the Body to Infection: I. Leukocytes, Granulocytes, the Monocyte-Macrophage System, and InflammationResistance of the Body to Infection: II. Immunity and AllergyBlood Types; Transfusion; Tissue and Organ TransplantationHemostasis and Blood CoagulationPulmonary VentilationPrinciples of Gas Exchange; Diffusion of Oxygen and Carbon Dioxide Through the Respiratory MembraneTransport of Oxygen and Carbon Dioxide in Blood and Tissue FluidsRespiratory Insufficiency—Pathophysiology, Diagnosis, Oxygen TherapyPhysiology of Deep-Sea Diving and Other Hyperbaric ConditionsOrganization of the Nervous System, Basic Functions of Synapses, and NeurotransmittersSensory Receptors, Neuronal Circuits for Processing InformationThe Eye: I. Optics of VisionThe Eye: II. Receptor and Neural Function of the RetinaCortical and Brain Stem Control of Motor FunctionContributions of the Cerebellum and Basal Ganglia to Overall Motor ControlCerebral Cortex, Intellectual Functions of the Brain, Learning, and MemoryBehavioral and Motivational Mechanisms of the Brain—The Limbic System and the HypothalamusStates of Brain Activity—Sleep, Brain Waves, Epilepsy, PsychosesThe Autonomic Nervous System and the Adrenal MedullaCerebral Blood Flow, Cerebrospinal Fluid, and Brain MetabolismGeneral Principles of Gastrointestinal Function—Motility, Nervous Control, and Blood CirculationPropulsion and Mixing of Food in the Alimentary TractSecretory Functions of the Alimentary TractMetabolism of Carbohydrates and Formation of Adenosine TriphosphateLipid MetabolismThe Liver as an OrganDietary Balances; Regulation of Feeding; Obesity and Starvation; Vitamins and MineralsEnergetics and Metabolic RateBody Temperature Regulation and FeverIntroduction to EndocrinologyPituitary Hormones and Their Control by the HypothalamusThyroid Metabolic HormonesAdrenocortical HormonesInsulin, Glucagon, and Diabetes MellitusParathyroid Hormone, Calcitonin, Calcium and Phosphate Metabolism, Vitamin D, Bone, and Teeth