Library/Health Professions and Related Programs/Guyton and Hall Textbook of Medical Physiology, 14th Edition/The Body Fluid Compartments: Extracellular and Intracellular Fluids; Interstitial Fluid and Edema

The Body Fluid Compartments: Extracellular and Intracellular Fluids; Interstitial Fluid and Edema

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Questions

Question 1

What is the primary factor that determines the distribution of fluid between the intracellular and extracellular compartments?

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Question 2

What is the calculated osmolarity in mOsm/L of a 0.9 percent sodium chloride solution, before applying the osmotic coefficient?

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Question 3

What happens to a cell when it is placed in a hypotonic solution with a lower concentration of impermeant solutes?

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Question 4

What is the primary difference between the terms 'isotonic' and 'isosmotic'?

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Question 5

What is the main effect of adding an isotonic saline solution to the extracellular fluid compartment?

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Question 6

According to the calculation example in the text, what is the approximate final extracellular fluid volume after infusing 2 liters of a 3.0 percent hypertonic sodium chloride solution into a 70-kg patient with an initial ECF volume of 14 liters?

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Question 7

What is the primary cellular-level consequence of rapid hyponatremia, particularly in the brain?

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Question 8

A condition characterized by the presence of excess fluid in the body tissues, which can involve both extracellular and intracellular compartments, is known as what?

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Question 9

Which of the following conditions is a primary cause of intracellular edema?

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Question 10

What are the two general causes of extracellular edema?

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Question 11

What is the term for a solution that will cause cells to shrink because it has a higher concentration of impermeant solutes?

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Question 12

What is the approximate osmolarity of a 5 percent glucose solution, making it nearly isotonic?

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Question 13

What is the net effect of adding a hypertonic solution to the extracellular fluid?

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Question 14

According to the text, what percentage of the total osmolarity of the interstitial fluid and plasma is due to sodium and chloride ions?

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Question 15

What is the term for a reduced plasma sodium concentration, typically below 142 mEq/L?

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Question 16

Which of the following conditions can cause hypernatremia, an elevated plasma sodium concentration?

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Question 17

What is the primary physiological effect of hypernatremia on the body's cells?

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Question 18

In the process of calculating fluid shifts after an infusion, what are the two fundamental principles that must be kept in mind?

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Question 19

In which part of the body do the diseases nephrotic syndrome and cirrhosis of the liver cause edema?

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Question 20

What is the approximate potential osmotic pressure that can develop across a cell membrane if the cell, with an intracellular osmolarity of 282 mOsm/L, is exposed to pure water?

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Question 21

Lymphedema, a severe form of extracellular edema, is caused by the failure of which system?

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Question 22

What is the term used to describe the type of edema where pressing a thumb against the tissue area leaves a pit for a few seconds?

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Question 23

What is the total safety factor against edema, which represents the theoretical rise in capillary pressure that can be tolerated before marked edema occurs?

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Question 24

What is the term for edema fluid that collects in a potential space like the abdominal cavity?

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Question 25

What is the normal interstitial fluid hydrostatic pressure in the pleural cavity?

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Question 26

What distinguishes nonpitting edema from pitting edema?

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Question 27

Which condition, leading to decreased plasma proteins, is described as a major cause of edema and involves damage to the membranes of the renal glomeruli?

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Question 28

What is the average interstitial fluid hydrostatic pressure in loose subcutaneous tissues, and how does this act as a safety factor against edema?

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Question 29

The term for an effusion, or collection of excess fluid, specifically within the abdominal cavity is known as what?

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Question 30

What is the reason that highly permeating substances like urea have little effect on intracellular volume under steady-state conditions?

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Question 31

Why is plasma osmolarity a reasonable indicator of a patient's fluid status in many clinical conditions?

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Question 32

A patient with adrenal insufficiency and overuse of diuretics is likely to present with which combination of conditions according to Table 25-4?

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Question 33

In a patient with slowly developing hyponatremia, how does the brain attenuate swelling?

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Question 34

What is the primary danger of correcting chronic hyponatremia too rapidly with hypertonic solutions?

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Question 35

What is considered a common cause of hypernatremia associated with decreased extracellular fluid volume?

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Question 36

Why might a patient with Cushing disease or primary aldosteronism develop hypernatremia-overhydration?

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Question 37

Below what plasma protein concentration does serious generalized edema typically occur?

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Question 38

How does liver cirrhosis contribute to the formation of ascites?

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Question 39

What is the role of interstitial gel, formed by a proteoglycan meshwork, in normal tissues?

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Question 40

What is the safety factor against edema provided by the 'washdown of interstitial fluid protein'?

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Question 41

How does the increased ability of lymph flow act as a safety factor against edema?

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Question 42

What is the osmotic coefficient of sodium chloride, and what does it account for?

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Question 43

In heart failure, what is the consequence of the heart failing to pump blood normally from the veins into the arteries regarding edema formation?

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Question 44

What is the definition of osmolality?

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Question 45

Why does adding a hypotonic solution to the extracellular fluid cause a greater increase in intracellular volume than in extracellular volume?

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Question 46

An infection with filarial nematodes (Wuchereria bancrofti) causes severe edema primarily by which mechanism?

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Question 47

According to the principles of osmosis, if a solute like sodium chloride is added to the extracellular fluid, what is the immediate response of water?

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Question 48

What is the primary reason for correcting the calculated osmolarity of a sodium chloride solution with an osmotic coefficient?

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Question 49

Which of the following is NOT listed as one of the three conditions especially prone to cause intracellular swelling (edema)?

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Question 50

In the summary of safety factors that prevent edema, what is the value of the safety factor caused by increased lymph flow?

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