Metabolism of Carbohydrates and Formation of Adenosine Triphosphate

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Questions

Question 1

According to experimental results, by how much can insulin increase the rate of glucose transport into a resting muscle cell?

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Question 2

What is the primary characteristic of brain cells regarding glucose uptake and usage?

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Question 3

At what range of blood glucose levels do symptoms of hypoglycemic shock, such as nervous irritability, typically develop?

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Question 4

What is the function of the enzyme glucokinase in liver cells following insulin stimulation?

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Question 5

What is the maximum percentage of liver mass that can be stored as glycogen?

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Question 6

Between meals, a lack of insulin, along with increased glucagon, activates which enzyme to cause the splitting of glycogen into glucose phosphate?

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Question 7

When the amount of glucose entering liver cells exceeds what can be stored as glycogen, what process does insulin promote?

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Question 8

In pancreatic beta cells, what is the direct effect of increased adenosine triphosphate (ATP) levels derived from glucose oxidation?

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Question 9

Which of the following is an effect of thyroid hormone on carbohydrate metabolism?

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Question 10

What is the best-known metabolic effect of cortisol on carbohydrate metabolism?

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Question 11

The condition called 'adrenal diabetes' is caused by an increase in blood glucose concentration that is occasionally great enough to be what percentage above normal?

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Question 12

What is the most important function of glucagon?

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Question 13

An injection of only 1 microgram per kilogram of glucagon can elevate blood glucose concentration by approximately how much in about 20 minutes?

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Question 14

During moderate or heavy exercise, how do muscles utilize large amounts of glucose without requiring large amounts of insulin?

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Question 15

When the liver functions as a blood glucose buffer system after a meal, approximately what proportion of the glucose absorbed from the gut is stored as glycogen?

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Question 16

How does insulin inhibit gluconeogenesis in the liver?

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Question 17

What is the primary controller of insulin secretion?

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Question 18

Which enzyme is considered the rate-limiting step for glucose metabolism in the pancreatic beta cell and the major mechanism for glucose sensing?

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Question 19

What is the effect of the hormones GLP-1 and GIP on insulin secretion?

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Question 20

How does cortisol cause mobilization of amino acids from extrahepatic tissues?

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Question 21

Which two factors are most potent in regulating aldosterone secretion?

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Question 22

What is the most obvious effect of growth hormone on the body?

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Question 23

How does growth hormone affect carbohydrate utilization?

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Question 24

For growth hormone to be effective in promoting growth, what two factors are necessary?

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Question 25

What is the primary action of the enzyme hormone-sensitive lipase in fat cells, and how is it affected by insulin deficiency?

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Question 26

In the absence of insulin, what is the consequence of excess fatty acids in the liver regarding acetoacetic acid?

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Question 27

Why is it important to maintain a constant blood glucose concentration?

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Question 28

Which of the following is a reason why an excessively high blood glucose concentration is detrimental?

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Question 29

What are the two major types of diabetes mellitus described in the text?

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Question 30

In severe, untreated diabetes mellitus, blood glucose can rise to what level?

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Question 31

What is the typical blood 'threshold' for the appearance of glucose in the urine?

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Question 32

Which condition is NOT a classic symptom of diabetes resulting from hyperglycemia and osmotic diuresis?

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Question 33

What is the primary cause of Type 2 diabetes?

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Question 34

What is the most important risk factor for Type 2 diabetes in both children and adults?

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Question 35

Which of the following is NOT a feature of the 'metabolic syndrome'?

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Question 36

Which of the following hormones does NOT play a major role in the 'switching' mechanism between carbohydrate and lipid metabolism?

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Question 37

Which hormone is especially important for increasing plasma glucose concentration during periods of stress when the sympathetic nervous system is excited?

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Question 38

What are the two major effects of glucagon on glucose metabolism?

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Question 39

During exhaustive exercise, blood glucagon concentration can increase by how much?

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Question 40

What is the principal role of somatostatin secreted from the delta cells of the islets of Langerhans?

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Question 41

What is the normal fasting blood glucose concentration in a person each morning before breakfast?

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Question 42

How long does it typically take for the feedback systems to return blood glucose concentration back to the control level after a carbohydrate meal?

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Question 43

Which hormone is NOT considered to have an anti-inflammatory effect?

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Question 44

What is the primary way cortisol prevents inflammation?

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Question 45

How do sulfonylurea drugs like glyburide and tolbutamide stimulate insulin secretion?

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Question 46

What is the plasma half-life of insulin, and why is this rapid clearance important?

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Question 47

Which hormone has its secretion stimulated by high concentrations of amino acids like alanine and arginine, promoting their rapid conversion to glucose?

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Question 48

In the mechanism of insulin action on a target cell, what is the direct result of insulin binding to the alpha subunits of its receptor?

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Question 49

In the two-stage response of insulin secretion to a sustained high glucose level, what causes the second, more prolonged rise in insulin secretion beginning at about 15 minutes?

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Question 50

What effect does increased thyroid hormone have on the body's basal metabolic rate (BMR)?

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