THE CYTOCHROME P450 SYSTEM

What is the primary function of the cytochrome P450 (CYP450) enzyme system in the body?

What is the effect of a drug that is an 'inducer' of the CYP450 system on another medication metabolized by the same enzyme?

If a medication is taken with an agent that 'inhibits' its metabolism through the CYP450 system, what is the likely outcome?

What percentage of drug metabolism is collectively handled by the CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 enzymes?

What percentage of Caucasians are described as poor metabolizers of drugs dependent on the CYP2D6 enzyme?

Which commonly ingested substance is listed as an inducer of the CYP1A2 enzyme?

The drug tamoxifen is biotransformed to its potent antiestrogen form, endoxifen, by which specific enzyme?

According to the provided tables, which medication is a substrate for the CYP2D6 enzyme?

Which of the following is listed as an inhibitor of the CYP2C19 enzyme?

An inducing agent can increase the rate of another drug's metabolism by how much, according to the text?

Which group of medications metabolized by the CYP2D6 enzyme is mentioned in the text's discussion on genetic variability?

What is the clinical consequence for a patient who is a 'poor metabolizer' of a drug that is normally inactivated by a specific CYP enzyme?

Based on the CYP3A table, which natural product is listed as an inducer of the CYP3A enzyme?

Which of the following drugs is listed as a substrate for the CYP1A2 enzyme?

If a patient taking losartan (a CYP2C9 substrate) also starts taking amiodarone (a CYP2C9 inhibitor), what is the likely interaction?

Which drug is an inducer of the CYP2C9 enzyme?

What is the key conclusion from the research mentioned on CYP2D6 metabolism and tamoxifen in post-menopausal women with early breast cancer?

Which medication is listed in the tables as an inhibitor of the CYP2D6 enzyme?

What is the potential consequence of taking antidepressants like paroxetine or fluoxetine with other drugs metabolized by CYP2D6, such as metoprolol?

Which drug is listed as a substrate of the CYP3A enzyme?

Which of the following is an inducer of the CYP3A enzyme, according to the provided table?

The text mentions that the effects of grapefruit juice inhibition can last for several days under what condition?

What is the term for the genetic variability that may influence a patient's response to commonly prescribed drug classes?

According to the CYP2D6 table, are there any inducers listed for this enzyme?

If a patient taking diazepam (a CYP2C19 substrate) starts taking rifampin (a CYP2C19 inducer), what is the most likely outcome?

Which medication is identified as both a substrate and an inhibitor of the CYP3A enzyme system?

What percentage of drug metabolism is attributed to the CYP2D6 enzyme alone?

Which of the following is listed in the tables as a substrate for the CYP2C9 enzyme?

In the context of the CYP450 system, what is the significance of the number '450'?

Which of the following drugs is listed as an inhibitor for both CYP1A2 and CYP2D6?

What is the primary reason the chapter emphasizes that nurses must understand the cytochrome P450 system?

Which drug is listed as an inducer for three different major enzyme systems: CYP1A2, CYP2C9, and CYP3A?

What is the effect of other citrus juices on the CYP450 system compared to grapefruit juice?

According to the CYP2C19 table, which drug is listed as an inducer?

What is the potential outcome when an antifungal that inhibits CYP3A4, such as ketoconazole, is taken with a statin metabolized by the same enzyme?

Which medication is a substrate for the CYP2C19 enzyme system?

Which drug is an inhibitor of the CYP3A enzyme system?

What is the range of percentage of African Americans who are poor metabolizers of drugs dependent on CYP2D6?

Which drug is listed as an inhibitor of the CYP1A2 enzyme?

Which enzyme is primarily responsible for metabolizing (S)-warfarin?

Which of the following drugs is a substrate for the CYP2D6 enzyme and is also an antidepressant?

The inhibition of the CYP450 enzyme system by grapefruit juice is described as being what?

According to the table for CYP2C9, which drug is listed as both a substrate and an inhibitor?

Which drug is listed as an inhibitor of CYP2C19?

What is the source of information regarding a drug's CYP450 metabolism and its potential for inhibition or induction?

Which medication is a substrate of CYP3A and also a calcium channel blocker?

Which of the following is an inducer of the CYP1A2 enzyme?

Which drug is an inhibitor of CYP2D6, according to the provided table?

The combination of what two factors can markedly reduce endoxifen plasma concentrations in tamoxifen-treated patients?

Which drug is identified as a substrate of CYP2C9?