Library/Biological and Biomedical Sciences/Lehninger Principles of Biochemistry/Biosynthesis of Amino Acids, Nucleotides, and Related Molecules

Biosynthesis of Amino Acids, Nucleotides, and Related Molecules

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Questions

Question 1

What is the primary function of leghemoglobin in the root nodules of leguminous plants during nitrogen fixation?

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Question 2

What is the net reaction for the combined action of glutamine synthetase and glutamate synthase in bacteria and plants?

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Question 3

According to the text, which of the following is NOT a characteristic of the regulation of E. coli glutamine synthetase?

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Question 4

What is the primary role of the coenzyme 5-phosphoribosyl-1-pyrophosphate (PRPP) in amino acid biosynthesis?

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Question 5

The biosynthesis of serine from 3-phosphoglycerate involves which sequence of general reactions?

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Question 6

In the catabolism of heme, what is the role of heme oxygenase?

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Question 7

What is the primary role of the coenzyme S-adenosylmethionine (adoMet)?

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Question 8

What is the consequence of the irreversibility of the reaction converting N5,N10-methylenetetrahydrofolate to N5-methyltetrahydrofolate in the context of vitamin B12 deficiency?

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Question 9

Which amino acid is NOT a member of the biosynthetic family derived from alpha-ketoglutarate?

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Question 10

What is the key structural feature of the enzyme glutamine amidotransferase?

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Question 11

Which statement accurately describes the initial committed step in de novo purine nucleotide synthesis?

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Question 12

How do mammals primarily synthesize phosphatidylethanolamine and phosphatidylcholine?

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Question 13

What is the primary mechanism by which the drug allopurinol treats gout?

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Question 14

What is the role of thioredoxin in the synthesis of deoxyribonucleotides?

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Question 15

What is the key difference between the de novo biosynthetic pathways for purines and pyrimidines?

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Question 16

How many ATP molecules are consumed in the overall reaction for biological nitrogen fixation to produce two molecules of ammonium ion?

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Question 17

What is the source of the five-carbon skeleton for the amino acid proline?

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Question 18

What is the role of allopurinol's metabolite, oxypurinol, in the treatment of gout?

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Question 19

The drug methotrexate is a potent inhibitor of which enzyme?

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Question 20

The disease Lesch-Nyhan syndrome is caused by a genetic lack of which enzyme activity?

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