The Innate and Adaptive Immune Systems

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Questions

Question 1

Which statement accurately distinguishes between the innate and adaptive immune systems?

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Question 2

What is the general term for the microbe-associated molecules that are recognized by the innate immune system's receptor proteins?

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Question 3

According to the text, approximately how many different Toll-like receptors (TLRs) does a human make?

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Question 4

Which Toll-like receptor (TLR) is responsible for recognizing lipopolysaccharide (LPS) on the outer membrane of Gram-negative bacteria?

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Question 5

What is described as the pivotal complement component that is cleaved and activated by all three pathways of complement activation?

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Question 6

How do Natural Killer (NK) cells primarily distinguish virus-infected cells from healthy cells?

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Question 7

Which cell type is described as the crucial link between the innate and adaptive immune systems because it ingests pathogens and presents their antigens to T cells?

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Question 8

What is the approximate number of lymphocytes in the human body, making the immune system comparable in cell mass to the liver or brain?

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Question 9

Where do T cells and B cells primarily develop, respectively, in adult mammals?

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Question 10

What is the key difference between a primary and a secondary immune response to the same antigen?

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Question 11

Which of the following is NOT listed as a mechanism for establishing immunological self-tolerance?

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Question 12

Which class of immunoglobulin is the first to be made by a developing B cell and is also the major class secreted in the early stages of a primary antibody response?

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Question 13

How many antigen-binding sites does a secreted IgM molecule have, due to its pentameric structure?

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Question 14

Which immunoglobulin class is secreted in the largest quantities during a secondary immune response and is capable of crossing the placenta from mother to fetus?

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Question 15

Which immunoglobulin class is primarily responsible for allergic reactions like hay fever and asthma by binding to Fc receptors on mast cells?

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Question 16

What is the primary function of the activation-induced deaminase (AID) enzyme in activated B cells?

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Question 17

What is a key structural difference between T cell receptors (TCRs) and B cell receptors (BCRs)?

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Question 18

To which cells do class I and class II MHC proteins primarily present foreign peptides, respectively?

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Question 19

What is the typical length of the peptides displayed in the peptide-binding groove of Class I MHC proteins?

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Question 20

From where do the peptides presented by class II MHC proteins on antigen-presenting cells (APCs) mainly originate?

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