Which immunoglobulin class is primarily responsible for allergic reactions like hay fever and asthma by binding to Fc receptors on mast cells?
Explanation
IgE is the immunoglobulin class associated with type I hypersensitivity (allergic) reactions. It binds with high affinity to Fcε receptors on mast cells and basophils. When an allergen cross-links the bound IgE, it triggers these cells to degranulate and release histamine and other inflammatory mediators, causing the symptoms of allergy.
Other questions
Which statement accurately distinguishes between the innate and adaptive immune systems?
What is the general term for the microbe-associated molecules that are recognized by the innate immune system's receptor proteins?
According to the text, approximately how many different Toll-like receptors (TLRs) does a human make?
Which Toll-like receptor (TLR) is responsible for recognizing lipopolysaccharide (LPS) on the outer membrane of Gram-negative bacteria?
What is described as the pivotal complement component that is cleaved and activated by all three pathways of complement activation?
How do Natural Killer (NK) cells primarily distinguish virus-infected cells from healthy cells?
Which cell type is described as the crucial link between the innate and adaptive immune systems because it ingests pathogens and presents their antigens to T cells?
What is the approximate number of lymphocytes in the human body, making the immune system comparable in cell mass to the liver or brain?
Where do T cells and B cells primarily develop, respectively, in adult mammals?
What is the key difference between a primary and a secondary immune response to the same antigen?
Which of the following is NOT listed as a mechanism for establishing immunological self-tolerance?
Which class of immunoglobulin is the first to be made by a developing B cell and is also the major class secreted in the early stages of a primary antibody response?
How many antigen-binding sites does a secreted IgM molecule have, due to its pentameric structure?
Which immunoglobulin class is secreted in the largest quantities during a secondary immune response and is capable of crossing the placenta from mother to fetus?
What is the primary function of the activation-induced deaminase (AID) enzyme in activated B cells?
What is a key structural difference between T cell receptors (TCRs) and B cell receptors (BCRs)?
To which cells do class I and class II MHC proteins primarily present foreign peptides, respectively?
What is the typical length of the peptides displayed in the peptide-binding groove of Class I MHC proteins?
From where do the peptides presented by class II MHC proteins on antigen-presenting cells (APCs) mainly originate?