Which two amino acids are exclusively ketogenic, meaning they are degraded to acetyl-CoA or acetoacetyl-CoA but cannot be converted to glucose?
Explanation
Amino acids are categorized as ketogenic or glucogenic based on their metabolic end products. Leucine and lysine are unique in that their carbon skeletons are degraded exclusively to acetyl-CoA or acetoacetyl-CoA, which can form ketone bodies but cannot be used for net synthesis of glucose.
Other questions
Under what metabolic circumstance do amino acids undergo oxidative degradation in animals?
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