What is the described effect of a LIFR (leukemia inhibitory factor receptor) knockout?
Explanation
This question highlights the critical developmental role of the LIF receptor, as its knockout leads to perinatal lethality and hematopoietic defects.
Other questions
What is the size and form of the Colony-stimulating factor G-CSF (CSF-3) according to the appendix on cytokines?
Which cells are listed as the producers of GM-CSF (granulocyte-macrophage colony-stimulating factor)?
What is the effect of a knockout of the M-CSF (CSF-1) receptor?
According to the appendix on cytokines, what are the actions of IFN-γ?
What are the receptors for the cytokine IL-1α?
What is the described effect of an IL-1β knockout?
What is the primary action of IL-1 RA (receptor antagonist) as described in the appendix?
What is the alternative name for IL-2 provided in the appendix on cytokines?
What common subunit is part of the receptor for IL-3 (multicolony CSF)?
Which of the following are listed as producer cells for IL-4 (BCGF-1, BSF-1)?
What is the size and form of the cytokine IL-5 (BCGF-2)?
What are the components of the IL-6 receptor according to the appendix?
What is the described effect of an IL-7 knockout on the immune system?
Which of the following is an action of IL-9?
What is the alternative name for IL-10 listed in the appendix on cytokines?
What are the producer cells for the cytokine IL-11?
What are the sizes of the two subunits of the heterodimeric cytokine IL-12?
What are the described actions of the interleukin IL-13?
Besides IL-15, what is the alternative name for the cytokine that shares receptors with IL-2?
What is the molecular form of IL-16 according to the appendix?
Which cells are listed as producers of IL-17A (mCTLA-8)?
What is the size in amino acids of the cytokine IL-17F (ML-1)?
Which cells produce IL-18 (IGIF, interferon-α inducing factor)?
Which receptors are used by IL-19?
Which of the following cell types are producers of IL-20?
What is the effect of an IL-21 knockout on the immune system?
What is the alternative name for the cytokine IL-22?
What is the molecular structure of the cytokine IL-23?
What are the actions of IL-24 (MDA-7)?
What is the receptor for the cytokine IL-25 (IL-17E)?
Which cells are listed as producers of IL-26 (AK155)?
What are the producer cells for the cytokine IL-27?
What is the primary action of IL-28A,B (IFN-B502,3)?
The cytokine IL-29 (IFN-λ1) belongs to which family?
What is the relationship between IL-30 and IL-27 as described in the appendix?
Which cell type is listed as the producer of IL-31?
According to the appendix, what is the action of IL-32 (NK4, TAIF)?
What are the components of the receptor for IL-33 (NF-HEV)?
What is the size and form of the cytokine IL-34 (C16orf77)?
What is the molecular structure of the cytokine IL-35?
Which cells are listed as producers of the IL-36 family of cytokines (IL-36α, β, λ)?
What is the size and form of the cytokine IL-37?
What are the components of the TSLP receptor?
What are the actions of OSM (oncostatin M)?
What is the size and form of TNF-α (cachectin)?
Which cells are listed as the primary producers of LT-α (lymphotoxin-α)?
What is the described action of Fas ligand (FasL)?
Which cells are listed as producers of Trail (AP0-2L)?
What is a key action of TGF-β1 as listed in the 'Unassigned' family of cytokines?