What is the potential interaction between allopurinol and mercaptopurine?
Explanation
A key drug interaction to be aware of is between allopurinol and mercaptopurine. Allopurinol blocks the enzyme responsible for breaking down mercaptopurine, leading to dangerously high levels of the chemotherapy drug and increased risk of severe toxicity.
Other questions
What is the general use of antineoplastic agents as described in the text?
According to the text, what is a primary reason for using antineoplastics in combinations?
Which class of antineoplastic agents is described as causing cross-linking of DNA and having a cell cycle-nonspecific effect?
What is the mechanism of action for Antimetabolites like fluorouracil and methotrexate?
According to the table of antineoplastics, which agent is an example of an Enzyme that works by depleting asparagine?
What is the effect on the cell cycle of Vinca Alkaloids such as vinblastine and vincristine?
What are the primary contraindications for the use of antineoplastic agents?
When assessing a patient on antineoplastic therapy with a low platelet count, for how long should pressure be applied to venipuncture sites?
What patient teaching is crucial regarding vaccinations for someone undergoing antineoplastic therapy?
Which of the following is an example of an Anthracycline that interferes with DNA and RNA synthesis?
What is the primary mechanism of action for Taxoids like docetaxel and paclitaxel?
What is a key nursing assessment for a patient on antineoplastic therapy to monitor for bone marrow depression?
In the event of an IV infiltration during antineoplastic therapy, what is the immediate nursing action?
What type of personal protective equipment should be worn when preparing antineoplastic agents for injection?
What advice should be given to a patient on antineoplastics regarding crowds and people with infections?
A patient on antineoplastic therapy is concerned about hair loss. What is the appropriate nursing action according to the text?
What is the primary evaluation outcome for a patient with leukemia undergoing antineoplastic therapy?
Which class of antineoplastic agents, including tamoxifen, alters the hormonal status in sensitive tumors?
What is the mechanism of action for Podophyllotoxin Derivatives like etoposide?
A patient on antineoplastic therapy reports fatigue, dyspnea, and orthostatic hypotension. What condition should the nurse monitor for?
According to the text, what is the effect of antineoplastics on a patient's antibody response and risk of adverse reactions to vaccines?
Which category of antineoplastic agents has an 'Unknown' effect on the cell cycle according to the provided table?
What is the recommended patient action when stomatitis or oral ulceration occurs during antineoplastic therapy?
Why should a patient on antineoplastic therapy be advised about birth control?
What is the mechanism of action for the antitumor antibiotic bleomycin?
What potential interaction exists between methotrexate and high doses of NSAIDs?
Which agent is listed as an example of an Enzyme Inhibitor that inhibits topoisomerase?
What is the primary purpose of administering allopurinol to a patient on antineoplastic therapy?
What is the primary action of hormonal agents that are Aromatase Inhibitors, such as anastrozole?
In which situations should antineoplastic agents be used cautiously according to the 'Precautions' section?
What is a general, additive interaction mentioned in the text for antineoplastics?
What should the nurse monitor to assess the nutritional status of a patient on antineoplastic therapy?
Where should solutions for injection of antineoplastic agents be prepared?
What is a potential consequence of dosing errors with antineoplastic agents mentioned in the text?
What should the nurse instruct a patient to report immediately if symptoms of infection occur?
What is the cell cycle effect for agents in the 'ENZYMES' category, such as asparaginase?
What patient teaching is required for a patient taking antineoplastics regarding oral hygiene and potential ulceration?
What is one of the desired evaluation outcomes for a patient with a solid tumor treated with antineoplastics?
Besides treating cancers, what is another use for some antineoplastic agents like cyclophosphamide and methotrexate?
What is the recommended fluid intake for a patient experiencing symptoms of gout during antineoplastic therapy?
Which two agents are listed as examples of Vinca Alkaloids in the mechanism of action table?
What is the general action of most antineoplastic agents on DNA, immune function, or hormonal status?
What specific patient teaching is mentioned regarding thrombocytopenia precautions?
What is the cell cycle effect of antineoplastic agents in the 'TAXOIDS' category?
What is the instruction for a patient who reports symptoms of gout, such as increased uric acid and joint pain?
What is the cell cycle specificity for irinotecan, an enzyme inhibitor that inhibits topoisomerase?
Some antineoplastic agents are available in lipid-based formulations. What is the stated advantage of these formulations?
What should a nurse assess for to monitor for infection during neutropenia?
What is the final step of patient teaching mentioned in the 'Patient/Family Teaching' section for antineoplastics?