CD80, also known as B7.1, is a co-stimulator that serves as a ligand for which two T-cell receptors?

Correct answer: CD28 and CTLA-4

Explanation

CD80 (B7.1) is a critical co-stimulatory molecule expressed on antigen-presenting cells. It interacts with two different receptors on T cells: the activating receptor CD28 and the inhibitory receptor CTLA-4, thereby providing a key point of immune regulation.

Other questions

Question 1

What is the primary function of the CD2 antigen, also known as T11 or LFA-2?

Question 2

According to the appendix on CD antigens, what are the molecular weights in kDa for the γ, δ, and ε chains of the CD3 antigen?

Question 3

On which of the following cell populations is the CD4 antigen expressed?

Question 4

What is the function of the CD5 antigen found on thymocytes and T cells?

Question 5

Besides T8, what are the other names listed for the CD8 antigen?

Question 6

The CD9 antigen is part of which protein family?

Question 7

What is the function of CD10, also known as CALLA?

Question 8

The CD11a antigen is a subunit of integrin LFA-1. Which molecules does it bind to?

Question 9

What are the other names listed for the CD11b antigen?

Question 10

What is the molecular weight of the CD11c antigen as listed in the appendix?

Question 11

What is the described function of CD14, which is expressed on myelomonocytic cells?

Question 12

CD15s, found on leukocytes and endothelium, functions as a ligand for which molecules?

Question 13

What is the function of CD16a (FcγRIIIa), which is expressed on NK cells?

Question 14

CD18, the integrin β2 subunit, is found on leukocytes. Which alpha subunits does it associate with?

Question 15

CD19 on B cells has a key function as part of a complex. Which other molecules does it form this complex with?

Question 16

What is the proposed function of CD20, which is found on B cells?

Question 17

CD21, also known as CR2, functions as a receptor for which two entities?

Question 18

What is the function of CD23, also known as FcεRII?

Question 19

The CD25 antigen, expressed on activated T cells and other cells, is also known by what name?

Question 20

What is the enzymatic function of CD26, which is highly expressed on Treg cells?

Question 21

The CD27 antigen functions as a co-stimulator for T and B cells by binding to which molecule?

Question 22

As the receptor for co-stimulatory signal 2, which two molecules does CD28 bind to for the activation of naive T cells?

Question 23

The CD30 antigen, which is a member of the TNF receptor family, enhances B and T cell proliferation by binding to which ligand?

Question 24

What is the function of CD31, also known as PECAM-1?

Question 25

The CD32 antigen is described as what type of receptor?

Question 26

CD34, expressed on hematopoietic precursors, functions as a ligand for which molecule?

Question 27

CD35, also known as Complement Receptor 1 (CR1), binds to which complement components?

Question 28

What is the enzymatic function of CD38, which is expressed on early B and T cells?

Question 29

CD40, found on B cells and macrophages, receives a co-stimulatory signal by binding to which ligand?

Question 30

What is another name for CD43, which is expressed on leukocytes but not resting B cells?

Question 31

What is the primary enzymatic function of CD45, which is found on all hematopoietic cells?

Question 32

The CD45RO isoform, a marker for memory T cells, is characterized by containing which exons?

Question 33

CD47, which is expressed on all cells, functions as an adhesion molecule by acting as a receptor for which molecule?

Question 34

What is another name for the CD49d antigen, which is an α4 integrin?

Question 35

What is the function of CD52, which is targeted by therapeutic antibodies to deplete T cells from bone marrow?

Question 36

CD54, also known as ICAM-1, binds to which two integrins?

Question 37

What is the function of CD55, also known as Decay accelerating factor (DAF)?

Question 38

What is the primary function of CD59, also known as Protectin?

Question 39

What is another name for CD62E, which is expressed on the endothelium?

Question 40

CD64 (FcγRI) is described as a high-affinity receptor for which immunoglobulin class?

Question 41

What is the function of the CD69 antigen, which is also known as the Activation Inducer Molecule (AIM)?

Question 42

The CD71 antigen, expressed on all proliferating cells, is also known as what?

Question 43

What is the function of the CD79α and β chains?

Question 45

The CD88 antigen functions as a receptor for which complement component?

Question 46

What is the well-known other name for the CD90 antigen, which is expressed on human prothymocytes?

Question 47

Which CD antigen, also known as Apo-1 or Fas, induces apoptosis when it binds its ligand?

Question 48

What is the molecular weight of the CD86 antigen, also known as B7.2?

Question 49

What is the function of the CD89 antigen, also known as FcαR?

Question 50

CD103 is described as which type of integrin?