A monoclonal antibody therapeutic is named with the suffix '-zumab'. What does this suffix indicate about the antibody's origin?
Explanation
The nomenclature for monoclonal antibody therapeutics provides information about their origin and degree of humanization, which correlates with their potential immunogenicity. The suffix '-zumab' signifies that the antibody has been 'humanized' by transferring only the complementarity-determining regions (CDRs) from a murine antibody into a human antibody framework, reducing its foreignness to the human immune system.
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